INTERESTS: Learning and memory, Alzheimer’s disease, MRI, Transgenic mouse
Abnormal behaviors and brain functions in Alzheimer’s disease Model mice: longitudinal studies.
Alzheimer’s disease (AD) is the most popular type of dementia and a severe neurodegenerative disease and accompanied by memory impairment. One of the major pathological features is amyloid plaques, which consist of oligomeric and fibrillary aggregates of amyloid-beta (Aβ). There are no effective treatment to prevent AD from progressing symptoms yet. Here, we longitudinally studied Alzheimer’s animal models to understand the pathophysiology of the disease. Transgenic mouse models which express Aβ precursor protein (APP) and its plaque in the brain more were used to get knowledge of AD according to amyloid cascade hypothesis. We performed behavioural, Magnetic Resonance Imaging (MRI), and histological study in two kind of APP transgenic mouse from young to old. Basic character was examined using Open-field test once or every two months until 11-month-old. Various cognitive learning was assessed in 11 months to understand the difference of memory functions between AD model and normally aged subject. APP mouse showed less spatial memory from young period and aversive memory. In the other APP model, we studied functional connectivity of brain networks using resting-state functional MRI. Reduced functional connectivity was found between hippocampus and several regions and coincided with some cognitive deficit. In future study, we are investigating the preventive treatment of AD in early stage.